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An RNA-based fluorescent biosensor for high-throughput analysis of the cGAS-cGAMP-STING pathway
In mammalian cells, the second messenger (2′-5′, 3′-5′) cyclic GMP-AMP (2′, 3′-cGAMP), is produced by the cytosolic DNA sensor cGAMP synthase (cGAS), and subsequently bound by stimulator of interferon genes (STING) to trigger interferon response. Thus, the cGAS-cGAMP-STING pathway plays a critical r...
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| 出版年: | Cell Chem Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5397252/ https://ncbi.nlm.nih.gov/pubmed/27889408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.10.014 |
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