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Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

Multiple sclerosis (MS) is an inflammatory CNS demyelinating disease in which remyelination largely fails. Transmembrane TNF (tmTNF) and TNF receptor 2 are important for remyelination in experimental MS models, but it is unknown whether soluble TNF (solTNF), a major proinflammatory factor, is involv...

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Foilsithe in:JCI Insight
Main Authors: Karamita, Maria, Barnum, Christopher, Möbius, Wiebke, Tansey, Malú G., Szymkowski, David E., Lassmann, Hans, Probert, Lesley
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396518/
https://ncbi.nlm.nih.gov/pubmed/28422748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87455
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