Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell‐fate decisions. We generated Zeb2 knockout (KO) mouse ESCs, subjected them as embryo...

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Bibliografiske detaljer
Udgivet i:Stem Cells
Main Authors: Stryjewska, Agata, Dries, Ruben, Pieters, Tim, Verstappen, Griet, Conidi, Andrea, Coddens, Kathleen, Francis, Annick, Umans, Lieve, van IJcken, Wilfred F. J., Berx, Geert, van Grunsven, Leo A., Grosveld, Frank G., Goossens, Steven, Haigh, Jody J., Huylebroeck, Danny
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396376/
https://ncbi.nlm.nih.gov/pubmed/27739137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2521
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