Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell‐fate decisions. We generated Zeb2 knockout (KO) mouse ESCs, subjected them as embryo...

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發表在:Stem Cells
Main Authors: Stryjewska, Agata, Dries, Ruben, Pieters, Tim, Verstappen, Griet, Conidi, Andrea, Coddens, Kathleen, Francis, Annick, Umans, Lieve, van IJcken, Wilfred F. J., Berx, Geert, van Grunsven, Leo A., Grosveld, Frank G., Goossens, Steven, Haigh, Jody J., Huylebroeck, Danny
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
主題:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396376/
https://ncbi.nlm.nih.gov/pubmed/27739137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2521
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