Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells

We previously demonstrated that coexpressing retinoic acid (RA) receptor gamma and liver receptor homolog‐1 (LRH1 or NR5A2) with OCT4, MYC, KLF4, and SOX2 (4F) rapidly reprograms mouse embryonic fibroblast cells (MEFs) into induced pluripotent stem cells (iPSCs). Here, we further explore the role of...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Yang, Jian, Wang, Wei, Ooi, Jolene, Campos, Lia S., Lu, Liming, Liu, Pentao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863141/
https://ncbi.nlm.nih.gov/pubmed/25546009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1926
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