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Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells

We previously demonstrated that coexpressing retinoic acid (RA) receptor gamma and liver receptor homolog‐1 (LRH1 or NR5A2) with OCT4, MYC, KLF4, and SOX2 (4F) rapidly reprograms mouse embryonic fibroblast cells (MEFs) into induced pluripotent stem cells (iPSCs). Here, we further explore the role of...

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Publicat a:Stem Cells
Autors principals: Yang, Jian, Wang, Wei, Ooi, Jolene, Campos, Lia S., Lu, Liming, Liu, Pentao
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863141/
https://ncbi.nlm.nih.gov/pubmed/25546009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1926
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