Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells

We previously demonstrated that coexpressing retinoic acid (RA) receptor gamma and liver receptor homolog‐1 (LRH1 or NR5A2) with OCT4, MYC, KLF4, and SOX2 (4F) rapidly reprograms mouse embryonic fibroblast cells (MEFs) into induced pluripotent stem cells (iPSCs). Here, we further explore the role of...

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Bibliografiske detaljer
Udgivet i:Stem Cells
Main Authors: Yang, Jian, Wang, Wei, Ooi, Jolene, Campos, Lia S., Lu, Liming, Liu, Pentao
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863141/
https://ncbi.nlm.nih.gov/pubmed/25546009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1926
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