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Enantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐organocatalysis

Detailed herein is the photochemical organocatalytic enantioselective α‐alkylation of aldehydes with (phenylsulfonyl)alkyl iodides. The chemistry relies on the direct photoexcitation of enamines to trigger the formation of reactive carbon‐centered radicals from iodosulfones, while the ground‐state c...

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Publicado en:Angew Chem Int Ed Engl
Main Authors: Filippini, Giacomo, Silvi, Mattia, Melchiorre, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396335/
https://ncbi.nlm.nih.gov/pubmed/28323367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201612045
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