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Enantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐organocatalysis

Detailed herein is the photochemical organocatalytic enantioselective α‐alkylation of aldehydes with (phenylsulfonyl)alkyl iodides. The chemistry relies on the direct photoexcitation of enamines to trigger the formation of reactive carbon‐centered radicals from iodosulfones, while the ground‐state c...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Filippini, Giacomo, Silvi, Mattia, Melchiorre, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396335/
https://ncbi.nlm.nih.gov/pubmed/28323367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201612045
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