Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

Studies in vivo and in vitro have suggested that the mechanism underlying Alzheimer’s disease (AD) neuropathogenesis is initiated by an interaction between the cellular prion protein (PrP(C)) and amyloid-β oligomers (Aβo). This PrP(C)-Aβo complex activates Fyn kinase which, in turn, hyperphosphoryla...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol Commun
Egile Nagusiak: Rubenstein, Richard, Chang, Binggong, Grinkina, Natalia, Drummond, Eleanor, Davies, Peter, Ruditzky, Meir, Sharma, Deep, Wang, Kevin, Wisniewski, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395835/
https://ncbi.nlm.nih.gov/pubmed/28420443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0435-7
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