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T-Tau and P-Tau in Brain and Blood from Natural and Experimental Prion Diseases
Synaptic abnormalities are prominent in prion disease pathogenesis and are responsible for functional deficits. The microtubule associated protein, Tau, binds to and stabilizes microtubules in axons ensuring axonal transport of synaptic components. Tau phosphorylation reduces its affinity for microt...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4668063/ https://ncbi.nlm.nih.gov/pubmed/26630676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143103 |
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