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T-Tau and P-Tau in Brain and Blood from Natural and Experimental Prion Diseases

Synaptic abnormalities are prominent in prion disease pathogenesis and are responsible for functional deficits. The microtubule associated protein, Tau, binds to and stabilizes microtubules in axons ensuring axonal transport of synaptic components. Tau phosphorylation reduces its affinity for microt...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rubenstein, Richard, Chang, Binggong, Petersen, Robert, Chiu, Allen, Davies, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668063/
https://ncbi.nlm.nih.gov/pubmed/26630676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143103
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