Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

Studies in vivo and in vitro have suggested that the mechanism underlying Alzheimer’s disease (AD) neuropathogenesis is initiated by an interaction between the cellular prion protein (PrP(C)) and amyloid-β oligomers (Aβo). This PrP(C)-Aβo complex activates Fyn kinase which, in turn, hyperphosphoryla...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Rubenstein, Richard, Chang, Binggong, Grinkina, Natalia, Drummond, Eleanor, Davies, Peter, Ruditzky, Meir, Sharma, Deep, Wang, Kevin, Wisniewski, Thomas
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395835/
https://ncbi.nlm.nih.gov/pubmed/28420443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0435-7
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