CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells

The human genome produces thousands of long non-coding RNAs (lncRNAs) – transcripts >200 nucleotides long that do not encode proteins. While critical roles in normal biology and disease have been revealed for a subset of lncRNAs, the function of the vast majority remains untested. Here, we develo...

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Publicado en:Science
Main Authors: Liu, S John, Horlbeck, Max A, Cho, Seung Woo, Birk, Harjus S, Malatesta, Martina, He, Daniel, Attenello, Frank J, Villalta, Jacqueline E, Cho, Min Y, Chen, Yuwen, Mandegar, Mohammad A, Olvera, Michael P, Gilbert, Luke A, Conklin, Bruce R, Chang, Howard Y, Weissman, Jonathan S, Lim, Daniel A
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394926/
https://ncbi.nlm.nih.gov/pubmed/27980086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah7111
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