Next-generation libraries for robust RNA interference-based genome-wide screens

Genetic screening based on loss-of-function phenotypes is a powerful discovery tool in biology. Although the recent development of clustered regularly interspaced short palindromic repeats (CRISPR)-based screening approaches in mammalian cell culture has enormous potential, RNA interference (RNAi)-b...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kampmann, Martin, Horlbeck, Max A., Chen, Yuwen, Tsai, Jordan C., Bassik, Michael C., Gilbert, Luke A., Villalta, Jacqueline E., Kwon, S. Chul, Chang, Hyeshik, Kim, V. Narry, Weissman, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491794/
https://ncbi.nlm.nih.gov/pubmed/26080438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508821112
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