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CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells
The human genome produces thousands of long non-coding RNAs (lncRNAs) – transcripts >200 nucleotides long that do not encode proteins. While critical roles in normal biology and disease have been revealed for a subset of lncRNAs, the function of the vast majority remains untested. Here, we develo...
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Publicado no: | Science |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5394926/ https://ncbi.nlm.nih.gov/pubmed/27980086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah7111 |
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