Correcting diastolic dysfunction by Ca(2+) desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Several cardiac troponin I (cTnI) mutations are associated with restrictive cardiomyopathy (RCM) in humans. We have created transgenic mice (cTnI(193His) mice) that express the corresponding human RCM R192H mutation. Phenotype of this RCM animal model includes restrictive ventricles, biatrial enlarg...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Mol Cell Cardiol
मुख्य लेखकों: Li, Yuejin, Charles, Pierre-Yves Jean, Nan, Changlong, Pinto, Jose Renato, Wang, Yingcai, Liang, Jingsheng, Wu, Gang, Tian, Jie, Feng, Han-Zhong, Potter, James D., Jin, JP, Huang, Xupei
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394742/
https://ncbi.nlm.nih.gov/pubmed/20580639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.04.017
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