Correcting diastolic dysfunction by Ca(2+) desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Several cardiac troponin I (cTnI) mutations are associated with restrictive cardiomyopathy (RCM) in humans. We have created transgenic mice (cTnI(193His) mice) that express the corresponding human RCM R192H mutation. Phenotype of this RCM animal model includes restrictive ventricles, biatrial enlarg...

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發表在:J Mol Cell Cardiol
Main Authors: Li, Yuejin, Charles, Pierre-Yves Jean, Nan, Changlong, Pinto, Jose Renato, Wang, Yingcai, Liang, Jingsheng, Wu, Gang, Tian, Jie, Feng, Han-Zhong, Potter, James D., Jin, JP, Huang, Xupei
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394742/
https://ncbi.nlm.nih.gov/pubmed/20580639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.04.017
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