Correcting diastolic dysfunction by Ca(2+) desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Several cardiac troponin I (cTnI) mutations are associated with restrictive cardiomyopathy (RCM) in humans. We have created transgenic mice (cTnI(193His) mice) that express the corresponding human RCM R192H mutation. Phenotype of this RCM animal model includes restrictive ventricles, biatrial enlarg...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Li, Yuejin, Charles, Pierre-Yves Jean, Nan, Changlong, Pinto, Jose Renato, Wang, Yingcai, Liang, Jingsheng, Wu, Gang, Tian, Jie, Feng, Han-Zhong, Potter, James D., Jin, JP, Huang, Xupei
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394742/
https://ncbi.nlm.nih.gov/pubmed/20580639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.04.017
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