Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations

OBJECTIVES: To explore the dose-dependent diastolic dysfunction and the mechanisms of heart failure and early death in transgenic (TG) mice modeling human restrictive cardiomyopathy (RCM). BACKGROUND: The first RCM mouse model (cTnI(193His) mice) carrying cardiac troponin I (cTnI) R193H mutation (mo...

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Publicado no:J Mol Cell Cardiol
Main Authors: Li, Yuejin, Zhang, Lei, Jean-Charles, Pierre-Yves, Nan, Changlong, Chen, Guozhen, Tian, Jie, Jin, J.-P., Gelb, Ira J., Huang, Xupei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394738/
https://ncbi.nlm.nih.gov/pubmed/23810866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.06.007
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