Restrictive Cardiomyopathy Caused by Troponin Mutations: Application of Disease Animal Models in Translational Studies

Cardiac troponin I (cTnI) plays a critical role in regulation of cardiac function. Studies have shown that the deficiency of cTnI or mutations in cTnI (particularly in the C-terminus of cTnI) results in diastolic dysfunction (impaired relaxation) due to an increased myofibril sensitivity to calcium....

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Vydáno v:Front Physiol
Hlavní autoři: Liu, Xiaoyan, Zhang, Lei, Pacciulli, Daniel, Zhao, Jianquan, Nan, Changlong, Shen, Wen, Quan, Junjun, Tian, Jie, Huang, Xupei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165243/
https://ncbi.nlm.nih.gov/pubmed/28066262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00629
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