Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

The metastatic organotropism has been one of the cancer's greatest mysteries since the ‘seed and soil' hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secrete...

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發表在:Nat Commun
Main Authors: Zhang, Haiyang, Deng, Ting, Liu, Rui, Bai, Ming, Zhou, Likun, Wang, Xia, Li, Shuang, Wang, Xinyi, Yang, Haiou, Li, Jialu, Ning, Tao, Huang, Dingzhi, Li, Hongli, Zhang, Le, Ying, Guoguang, Ba, Yi
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394240/
https://ncbi.nlm.nih.gov/pubmed/28393839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15016
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