Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

The metastatic organotropism has been one of the cancer's greatest mysteries since the ‘seed and soil' hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secrete...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Haiyang, Deng, Ting, Liu, Rui, Bai, Ming, Zhou, Likun, Wang, Xia, Li, Shuang, Wang, Xinyi, Yang, Haiou, Li, Jialu, Ning, Tao, Huang, Dingzhi, Li, Hongli, Zhang, Le, Ying, Guoguang, Ba, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394240/
https://ncbi.nlm.nih.gov/pubmed/28393839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15016
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