Genomic heterogeneity and exceptional response to dual pathway inhibition in anaplastic thyroid cancer

PURPOSE: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinom...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Gibson, William J., Ruan, Daniel T., Paulson, Vera A., Barletta, Justine A., Hanna, Glenn J., Kraft, Stefan, Calles, Antonio, Nehs, Matthew A., Moore, Francis D., Taylor-Weiner, Amaro, Wala, Jeremiah, Zack, Travis I., Lee, Thomas C., Fennessy, Fiona M., Alexander, Erik K., Thomas, Tom, Janne, Pasi A., Garraway, Levi A., Carter, Scott L., Beroukhim, Rameen, Lorch, Jochen H., Van Allen, Eliezer M.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393965/
https://ncbi.nlm.nih.gov/pubmed/27797976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2154-T
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