Genomic heterogeneity and exceptional response to dual pathway inhibition in anaplastic thyroid cancer

PURPOSE: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinom...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Gibson, William J., Ruan, Daniel T., Paulson, Vera A., Barletta, Justine A., Hanna, Glenn J., Kraft, Stefan, Calles, Antonio, Nehs, Matthew A., Moore, Francis D., Taylor-Weiner, Amaro, Wala, Jeremiah, Zack, Travis I., Lee, Thomas C., Fennessy, Fiona M., Alexander, Erik K., Thomas, Tom, Janne, Pasi A., Garraway, Levi A., Carter, Scott L., Beroukhim, Rameen, Lorch, Jochen H., Van Allen, Eliezer M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393965/
https://ncbi.nlm.nih.gov/pubmed/27797976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2154-T
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