Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordin...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Wagle, Nikhil, Grabiner, Brian C., Van Allen, Eliezer M., Amin-Mansour, Ali, Taylor-Weiner, Amaro, Rosenberg, Mara, Gray, Nathanael, Barletta, Justine A., Guo, Yanan, Swanson, Scott J., Ruan, Daniel T., Hanna, Glenn J., Haddad, Robert I., Getz, Gad, Kwiatkowski, David J., Carter, Scott L., Sabatini, David M., Jänne, Pasi A., Garraway, Levi A., Lorch, Jochen H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564868/
https://ncbi.nlm.nih.gov/pubmed/25295501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1403352
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