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Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis
Although forming a heterodimer or heterooligomer is essential for MDM2 and MDMX to fully control p53 during early embryogenesis, deletion of either MDM2 or MDMX in specific tissues using the loxp-Cre system reveals phenotypic diversity during organ morphogenesis, which can be completely rescued by l...
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| Publié dans: | Dev Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5393629/ https://ncbi.nlm.nih.gov/pubmed/25263199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.09.017 |
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