Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease

Recessive Stargardt macular degeneration (STGD1) is caused by mutations in the gene for the ABCA4 transporter in photoreceptor outer segments. STGD1 patients and Abca4(−/−) (STGD1) mice exhibit buildup of bisretinoid-containing lipofuscin pigments in the retinal pigment epithelium (RPE), increased o...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Lenis, Tamara L., Sarfare, Shanta, Jiang, Zhichun, Lloyd, Marcia B., Bok, Dean, Radu, Roxana A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2017
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393232/
https://ncbi.nlm.nih.gov/pubmed/28348233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620299114
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