Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration

Accumulation of vitamin A-derived lipofuscin fluorophores in the retinal pigment epithelium (RPE) is a pathologic feature of recessive Stargardt macular dystrophy, a blinding disease caused by dysfunction or loss of the ABCA4 transporter in rods and cones. Age-related macular degeneration, a prevale...

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Hlavní autoři: Radu, Roxana A., Hu, Jane, Yuan, Quan, Welch, Darcy L., Makshanoff, Jacob, Lloyd, Marcia, McMullen, Stephen, Travis, Gabriel H., Bok, Dean
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099675/
https://ncbi.nlm.nih.gov/pubmed/21464132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191866
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