BCL6 promotes glioma and serves as a therapeutic target

ZBTB transcription factors orchestrate gene transcription during tissue development. However, their roles in glioblastoma (GBM) remain unexplored. Here, through a functional screening of ZBTB genes, we identify that BCL6 is required for GBM cell viability and that BCL6 overexpression is associated w...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Xu, Liang, Chen, Ye, Dutra-Clarke, Marina, Mayakonda, Anand, Hazawa, Masaharu, Savinoff, Steve E., Doan, Ngan, Said, Jonathan W., Yong, William H., Watkins, Ashley, Yang, Henry, Ding, Ling-Wen, Jiang, Yan-Yi, Tyner, Jeffrey W., Ching, Jianhong, Kovalik, Jean-Paul, Madan, Vikas, Chan, Shing-Leng, Müschen, Markus, Breunig, Joshua J., Lin, De-Chen, Koeffler, H. Phillip
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393201/
https://ncbi.nlm.nih.gov/pubmed/28356518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609758114
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