Genomic and functional analysis of the E3 ligase PARK2 in glioma

PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. In this study, we report that PARK2 is frequently deleted and underexpressed in human glioma, and low PARK2 expre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Lin, De-Chen, Xu, Liang, Chen, Ye, Yan, Haiyan, Hazawa, Masaharu, Doan, Ngan, Said, Jonathan W., Ding, Ling-Wen, Liu, Li-Zhen, Yang, Henry, Yu, Shizhu, Kahn, Michael, Yin, Dong, Koeffler, H. Phillip
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417379/
https://ncbi.nlm.nih.gov/pubmed/25877876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1433
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