Genomic and functional analysis of the E3 ligase PARK2 in glioma

PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. In this study, we report that PARK2 is frequently deleted and underexpressed in human glioma, and low PARK2 expre...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Lin, De-Chen, Xu, Liang, Chen, Ye, Yan, Haiyan, Hazawa, Masaharu, Doan, Ngan, Said, Jonathan W., Ding, Ling-Wen, Liu, Li-Zhen, Yang, Henry, Yu, Shizhu, Kahn, Michael, Yin, Dong, Koeffler, H. Phillip
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417379/
https://ncbi.nlm.nih.gov/pubmed/25877876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1433
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