Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer

PURPOSE: Sensitivity to a tyrosine kinase inhibitor (TKI) is correlated with the presence of somatic mutations that affect the kinase domain of epidermal growth factor receptor (EGFR). Development of resistance to TKI is a major therapeutic problem in non-small cell lung cancer (NSCLC). Aim of this...

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Autori principali: Sudo, Makoto, Chin, Tan Min, Mori, Seiichi, Doan, Ngan B., Said, Jonathan W., Akashi, Makoto, Koeffler, H. Phillip
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636434/
https://ncbi.nlm.nih.gov/pubmed/23515752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2132-y
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