Essential role for centromeric factors following p53 loss and oncogenic transformation

In mammals, centromere definition involves the histone variant CENP-A (centromere protein A), deposited by its chaperone, HJURP (Holliday junction recognition protein). Alterations in this process impair chromosome segregation and genome stability, which are also compromised by p53 inactivation in c...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Filipescu, Dan, Naughtin, Monica, Podsypanina, Katrina, Lejour, Vincent, Wilson, Laurence, Gurard-Levin, Zachary A., Orsi, Guillermo A., Simeonova, Iva, Toufektchan, Eleonore, Attardi, Laura D., Toledo, Franck, Almouzni, Geneviève
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393061/
https://ncbi.nlm.nih.gov/pubmed/28356341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290924.116
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