Essential role for centromeric factors following p53 loss and oncogenic transformation

In mammals, centromere definition involves the histone variant CENP-A (centromere protein A), deposited by its chaperone, HJURP (Holliday junction recognition protein). Alterations in this process impair chromosome segregation and genome stability, which are also compromised by p53 inactivation in c...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Filipescu, Dan, Naughtin, Monica, Podsypanina, Katrina, Lejour, Vincent, Wilson, Laurence, Gurard-Levin, Zachary A., Orsi, Guillermo A., Simeonova, Iva, Toufektchan, Eleonore, Attardi, Laura D., Toledo, Franck, Almouzni, Geneviève
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393061/
https://ncbi.nlm.nih.gov/pubmed/28356341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290924.116
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