Essential role for centromeric factors following p53 loss and oncogenic transformation

In mammals, centromere definition involves the histone variant CENP-A (centromere protein A), deposited by its chaperone, HJURP (Holliday junction recognition protein). Alterations in this process impair chromosome segregation and genome stability, which are also compromised by p53 inactivation in c...

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Detalles Bibliográficos
Publicado en:Genes Dev
Autores principales: Filipescu, Dan, Naughtin, Monica, Podsypanina, Katrina, Lejour, Vincent, Wilson, Laurence, Gurard-Levin, Zachary A., Orsi, Guillermo A., Simeonova, Iva, Toufektchan, Eleonore, Attardi, Laura D., Toledo, Franck, Almouzni, Geneviève
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393061/
https://ncbi.nlm.nih.gov/pubmed/28356341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290924.116
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