Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

BACKGROUND: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefore a promising target for GBM treatment. Our group identified the cellular prio...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Iglesia, Rebeca Piatniczka, Prado, Mariana Brandão, Cruz, Lilian, Martins, Vilma Regina, Santos, Tiago Góss, Lopes, Marilene Hohmuth
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392955/
https://ncbi.nlm.nih.gov/pubmed/28412969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0518-1
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