Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

BACKGROUND: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefore a promising target for GBM treatment. Our group identified the cellular prio...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Iglesia, Rebeca Piatniczka, Prado, Mariana Brandão, Cruz, Lilian, Martins, Vilma Regina, Santos, Tiago Góss, Lopes, Marilene Hohmuth
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392955/
https://ncbi.nlm.nih.gov/pubmed/28412969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0518-1
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