Measuring niacin-associated skin toxicity (NASTy) stigmata along with symptoms to aid development of niacin mimetics

Though cardioprotective, niacin monotherapy is limited by unpleasant cutaneous symptoms mimicking dermatitis: niacin-associated skin toxicity (NASTy). Niacin is prototypical of several emerging drugs suffering off-target rubefacient properties whereby agonizing the GPR109A receptor on cutaneous immu...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Dunbar, Richard L., Goel, Harsh, Tuteja, Sony, Song, Wen-Liang, Nathanson, Grace, Babar, Zeeshan, Lalic, Dusanka, Gelfand, Joel M., Rader, Daniel J., Grove, Gary L.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2017
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Methods
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392735/
https://ncbi.nlm.nih.gov/pubmed/28119443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D071696
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