Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

Tumor suppressor genes and their effector pathways have been identified for many dominantly heritable cancers, enabling efforts to intervene early in the course of disease. Our approach on the subject of early intervention was to investigate gene expression patterns of morphologically normal one-hit...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Peri, Suraj, Caretti, Elena, Tricarico, Rossella, Devarajan, Karthik, Cheung, Mitchell, Sementino, Eleonora, Menges, Craig W., Nicolas, Emmanuelle, Vanderveer, Lisa A., Howard, Sharon, Conrad, Peggy, Crowell, James A., Campbell, Kerry S., Ross, Eric A., Godwin, Andrew K., Yeung, Anthony T., Clapper, Margie L., Uzzo, Robert G., Henske, Elizabeth P., Ricketts, Christopher J., Vocke, Cathy D., Linehan, W. Marston, Testa, Joseph R., Bellacosa, Alfonso, Kopelovich, Levy, Knudson, Alfred G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392274/
https://ncbi.nlm.nih.gov/pubmed/27682873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12192
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