Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression

Thymine DNA Glycosylase (TDG) is a base excision repair enzyme that acts as a thymine and uracil DNA N-glycosylase on G:T and G:U mismatches, thus protecting CpG sites in the genome from mutagenesis by deamination. In addition, TDG has an epigenomic function by removing the novel cytosine derivative...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xu, Jinfei, Cortellino, Salvatore, Tricarico, Rossella, Chang, Wen-Chi, Scher, Gabrielle, Devarajan, Karthik, Slifker, Michael, Moore, Robert, Bassi, Maria Rosaria, Caretti, Elena, Clapper, Margie, Cooper, Harry, Bellacosa, Alfonso
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685726/
https://ncbi.nlm.nih.gov/pubmed/29163805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21219
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