Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

DNA methylation is a major epigenetic mechanism for gene silencing. While methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved. Here we show that...

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Main Authors: Cortellino, Salvatore, Xu, Jinfei, Sannai, Mara, Moore, Robert, Caretti, Elena, Cigliano, Antonio, Le Coz, Madeleine, Devarajan, Karthik, Wessels, Andy, Soprano, Dianne, Abramowitz, Lara K., Bartolomei, Marisa S., Rambow, Florian, Bassi, Maria Rosaria, Bruno, Tiziana, Fanciulli, Maurizio, Renner, Catherine, Klein-Szanto, Andres J., Matsumoto, Yoshihiro, Kobi, Dominique, Davidson, Irwin, Alberti, Christophe, Larue, Lionel, Bellacosa, Alfonso
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230223/
https://ncbi.nlm.nih.gov/pubmed/21722948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.020
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