Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

DNA methylation is a major epigenetic mechanism for gene silencing. While methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved. Here we show that...

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Autors principals: Cortellino, Salvatore, Xu, Jinfei, Sannai, Mara, Moore, Robert, Caretti, Elena, Cigliano, Antonio, Le Coz, Madeleine, Devarajan, Karthik, Wessels, Andy, Soprano, Dianne, Abramowitz, Lara K., Bartolomei, Marisa S., Rambow, Florian, Bassi, Maria Rosaria, Bruno, Tiziana, Fanciulli, Maurizio, Renner, Catherine, Klein-Szanto, Andres J., Matsumoto, Yoshihiro, Kobi, Dominique, Davidson, Irwin, Alberti, Christophe, Larue, Lionel, Bellacosa, Alfonso
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230223/
https://ncbi.nlm.nih.gov/pubmed/21722948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.020
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