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Klotho regulates CA1 hippocampal synaptic plasticity
Global klotho overexpression extends lifespan while global klotho-deficiency shortens it. As well, klotho protein manipulations inversely regulate cognitive function. Mice without klotho develop rapid onset cognitive impairment before they are 2 months old. Meanwhile, adult mice overexpressing kloth...
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| Publicat a: | Neuroscience |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5392240/ https://ncbi.nlm.nih.gov/pubmed/28215989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2017.02.006 |
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