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Klotho regulates CA1 hippocampal synaptic plasticity

Global klotho overexpression extends lifespan while global klotho-deficiency shortens it. As well, klotho protein manipulations inversely regulate cognitive function. Mice without klotho develop rapid onset cognitive impairment before they are 2 months old. Meanwhile, adult mice overexpressing kloth...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuroscience
Prif Awduron: Li, Qin, Vo, Hai T., Wang, Jing, Fox-Quick, Stephanie, Dobrunz, Lynn E., King, Gwendalyn D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392240/
https://ncbi.nlm.nih.gov/pubmed/28215989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2017.02.006
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