Effect of acute fentanyl treatment on synaptic plasticity in the hippocampal CA1 region in rats

Postoperative cognitive dysfunction (POCD), mainly characterized by short-term decline of learning and memory, occurs after operations under anesthesia. However, the underlying mechanisms are poorly understood. The μ-opioid receptors (MOR) are highly expressed in interneurons of hippocampus, and is...

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Detalhes bibliográficos
Main Authors: Hai eTian, Yueming eXu, Fucun eLiu, Guowei eWang, Sanjue eHu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-10-01
Colecção:Frontiers in Pharmacology
Assuntos:
Fentanyl
Hippocampus
Interneurons
LTP
μ-opioid receptor
FEPSP
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00251/full
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