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Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss

Although the absence of the age-regulating klotho protein causes klotho-deficient mice to rapidly develop cognitive impairment and increasing klotho enhances hippocampal-dependent memory, the cellular effects of klotho that mediate hippocampal-dependent memory function are unknown. Here we show prem...

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Bibliografske podrobnosti
izdano v:Neurobiol Aging
Main Authors: Laszczyk, Ann M., Fox-Quick, Stephanie, Vo, Hai T., Nettles, Dailey, Pugh, Phyllis C., Overstreet-Wadiche, Linda, King, Gwendalyn D.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612914/
https://ncbi.nlm.nih.gov/pubmed/28837861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.07.008
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