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Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

The chemokine receptor CXCR4 is activated by its unique chemokine ligand CXCL12 and regulates many physiological and developmental processes such as hematopoietic cell trafficking. CXCR4 is also one of the main co-receptors for human immunodeficiency virus (HIV) entry. Dysfunction of the CXCL12/CXCR...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Van Hout, Anneleen, D’huys, Thomas, Oeyen, Merel, Schols, Dominique, Van Loy, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391968/
https://ncbi.nlm.nih.gov/pubmed/28410420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176057
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