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Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

The chemokine receptor CXCR4 is activated by its unique chemokine ligand CXCL12 and regulates many physiological and developmental processes such as hematopoietic cell trafficking. CXCR4 is also one of the main co-receptors for human immunodeficiency virus (HIV) entry. Dysfunction of the CXCL12/CXCR...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Van Hout, Anneleen, D’huys, Thomas, Oeyen, Merel, Schols, Dominique, Van Loy, Tom
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391968/
https://ncbi.nlm.nih.gov/pubmed/28410420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176057
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