Ca(V)2.3 calcium channels control second-phase insulin release

Concerted activation of different voltage-gated Ca((2+)) channel isoforms may determine the kinetics of insulin release from pancreatic islets. Here we have elucidated the role of R-type Ca(V)2.3 channels in that process. A 20% reduction in glucose-evoked insulin secretion was observed in Ca(V)2.3-k...

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Main Authors: Jing, Xingjun, Li, Dai-Qing, Olofsson, Charlotta S., Salehi, Albert, Surve, Vikas V., Caballero, José, Ivarsson, Rosita, Lundquist, Ingmar, Pereverzev, Alexey, Schneider, Toni, Rorsman, Patrik, Renström, Erik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC539196/
https://ncbi.nlm.nih.gov/pubmed/15630454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522518
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