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Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule(−/−) Mice Due to Defective Reorganization of the Submembrane F-Actin Network

The neural cell adhesion molecule (NCAM) is required for cell type segregation during pancreatic islet organogenesis. We have investigated the functional consequences of ablating NCAM on pancreatic β-cell function. In vivo, NCAM(−/−) mice exhibit impaired glucose tolerance and basal hyperinsulinemia...

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Detalhes bibliográficos
Main Authors: Olofsson, Charlotta S., Håkansson, Joakim, Salehi, Albert, Bengtsson, Martin, Galvanovskis, Juris, Partridge, Chris, SörhedeWinzell, Maria, Xian, Xiaojie, Eliasson, Lena, Lundquist, Ingmar, Semb, Henrik, Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703535/
https://ncbi.nlm.nih.gov/pubmed/19213846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0475
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