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Palmitate increases L-type Ca(2+) currents and the size of the readily releasable granule pool in mouse pancreatic β-cells

We have investigated the in vitro effects of the saturated free fatty acid palmitate on mouse pancreatic β-cells by a combination of electrophysiological recordings, intracellular Ca(2+) ([Ca(2+)](i)) microfluorimetry and insulin release measurements. Addition of palmitate (1 mm, bound to fatty acid...

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Detalhes bibliográficos
Main Authors: Olofsson, Charlotta S, Salehi, Albert, Holm, Cecilia, Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665160/
https://ncbi.nlm.nih.gov/pubmed/15090611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.066258
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