Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia

The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the pacemaker activity in the heart, and its malfunction can result in heart disorders. One such disorder, familial sinus bradycardia, is caused by the S672R mutation in HCN, whose electrophysiological phenotype...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Boulton, Stephen, Akimoto, Madoka, Akbarizadeh, Sam, Melacini, Giuseppe
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391768/
https://ncbi.nlm.nih.gov/pubmed/28174302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773697
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