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Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states
Allosteric modulation provides an effective avenue for selective and potent enzyme inhibition. Here, we summarize and critically discuss recent advances on the mechanisms of allosteric partial agonists for three representative signalling enzymes activated by cyclic nucleotides: the cAMP-dependent pr...
Zapisane w:
| Wydane w: | Comput Struct Biotechnol J |
|---|---|
| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Research Network of Computational and Structural Biotechnology
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7720024/ https://ncbi.nlm.nih.gov/pubmed/33335680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.10.026 |
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