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Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the pacemaker activity in the heart, and its malfunction can result in heart disorders. One such disorder, familial sinus bradycardia, is caused by the S672R mutation in HCN, whose electrophysiological phenotype...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391768/ https://ncbi.nlm.nih.gov/pubmed/28174302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773697 |
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