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Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the pacemaker activity in the heart, and its malfunction can result in heart disorders. One such disorder, familial sinus bradycardia, is caused by the S672R mutation in HCN, whose electrophysiological phenotype...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391768/ https://ncbi.nlm.nih.gov/pubmed/28174302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773697 |
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